Optogenetic experimentation on astrocytes
نویسندگان
چکیده
منابع مشابه
Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters
The brain consists of heterogeneous populations of neuronal and non-neuronal cells. The revelation of their connections and interactions is fundamental to understanding normal brain functions as well as abnormal changes in pathological conditions. Optogenetics and chemogenetics have been developed to allow functional manipulations both in vitro and in vivo to examine causal relationships betwee...
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Astrocytes modulate synaptic transmission via release of gliotransmitters such as ATP, glutamate, D-serine and L-lactate. One of the main problems when studying the role of astrocytes in vitro and in vivo is the lack of suitable tools for their selective activation. Optogenetic actuators can be used to manipulate astrocytic activity by expression of variants of channelrhodopsin-2 (ChR2) or othe...
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A distributed network of neurons regulates wake, non-rapid eye movement (NREM) sleep, and REM sleep. However, there are also glia in the brain, and there is growing evidence that neurons and astroglia communicate intimately to regulate behaviour. To identify the effect of optogenetic stimulation of astrocytes on sleep, the promoter for the astrocyte-specific cytoskeletal protein, glial fibrilla...
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While glial activation is an integral part of pain pathogenesis, the existence of a causal relationship between glia and pain processing has yet to be demonstrated in vivo. Here, we have investigated whether the activation of spinal astrocytes could directly evoke pain hypersensitivity in vivo via the use of optogenetic techniques. Optogenetic stimulation of channelrhopdopsin-2 (ChR)-expressing...
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We focus on two-player, two-armed bandit games. We analyze the joint effect on the informational spillovers between the players of the correlation between the risky arms, and the extent to which one’s experimentation results are publicly disclosed. Our main results only depend on whethert informational shocks bring good or bad news. In the latter case, there is a sense in which the marginal val...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 2010
ISSN: 0958-0670
DOI: 10.1113/expphysiol.2010.052597